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A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering Mutations
Understanding the topologies and functions of protein interaction networks requires the selective removal of single interactions. We introduce a selection strategy that enriches among a random library of alleles for mutations that impair the binding to a given partner protein. The selection makes us...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015938/ https://www.ncbi.nlm.nih.gov/pubmed/27402358 http://dx.doi.org/10.1534/g3.116.031369 |