Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

Amyloid deposits formed from islet amyloid polypeptide (IAPP) are a hallmark of type 2 diabetes mellitus and are known to be cytotoxic to pancreatic β-cells. The molecular structure of the fibrillar form of IAPP is subject of intense research, and to date, different models exist. We present results...

Descripción completa

Detalles Bibliográficos
Autores principales: Weirich, Franziska, Gremer, Lothar, Mirecka, Ewa A., Schiefer, Stephanie, Hoyer, Wolfgang, Heise, Henrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015977/
https://www.ncbi.nlm.nih.gov/pubmed/27607147
http://dx.doi.org/10.1371/journal.pone.0161243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015977/
https://www.ncbi.nlm.nih.gov/pubmed/27607147
http://dx.doi.org/10.1371/journal.pone.0161243

Ejemplares similares