The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

The structure of the infectious prion protein (PrP(Sc)), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrP(Sc) replicates by converting the non-infectious...

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Detalles Bibliográficos
Autores principales: Vázquez-Fernández, Ester, Vos, Matthijn R., Afanasyev, Pavel, Cebey, Lino, Sevillano, Alejandro M., Vidal, Enric, Rosa, Isaac, Renault, Ludovic, Ramos, Adriana, Peters, Peter J., Fernández, José Jesús, van Heel, Marin, Young, Howard S., Requena, Jesús R., Wille, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015997/
https://www.ncbi.nlm.nih.gov/pubmed/27606840
http://dx.doi.org/10.1371/journal.ppat.1005835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015997/
https://www.ncbi.nlm.nih.gov/pubmed/27606840
http://dx.doi.org/10.1371/journal.ppat.1005835

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