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The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
The structure of the infectious prion protein (PrP(Sc)), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrP(Sc) replicates by converting the non-infectious...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015997/ https://www.ncbi.nlm.nih.gov/pubmed/27606840 http://dx.doi.org/10.1371/journal.ppat.1005835 |