Cargando…

Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa

Lipid A (also known as endotoxin) is the hydrophobic portion of lipopolysaccharides. It is an essential membrane component required for the viability of gram-negative bacteria. The enzymes involved in its biosynthesis are attractive targets for the development of novel antibiotics. LpxH catalyzes th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okada, Chiaki, Wakabayashi, Hiroko, Kobayashi, Momoko, Shinoda, Akira, Tanaka, Isao, Yao, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016852/ https://www.ncbi.nlm.nih.gov/pubmed/27609419 http://dx.doi.org/10.1038/srep32822

Ejemplares similares

Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis
por: Cho, Jae, et al.
Publicado: (2016)

Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606
por: Richie, Daryl L., et al.
Publicado: (2016)

Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis
por: Young, Hayley E., et al.
Publicado: (2016)

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
por: Kroeck, Kyle G., et al.
Publicado: (2019)

dCTP Pyrophosphohydrase Exhibits Nucleic Accumulation in Multiple Carcinomas
por: Zhang, Y., et al.
Publicado: (2013)

3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors
por: Zuo, Ke, et al.
Publicado: (2017)

Structure-Based Virtual Screening of Pseudomonas aeruginosa LpxA Inhibitors using Pharmacophore-Based Approach
por: Bhaskar, Baki Vijaya, et al.
Publicado: (2020)

Pharmacoinformatics approaches to identify potential hits against tetraacyldisaccharide 4′-kinase (LpxK) of Pseudomonas aeruginosa
por: Damale, Manoj G., et al.
Publicado: (2020)

Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
por: Bohl, Heather O., et al.
Publicado: (2018)

Identification of lptA, lpxE, and lpxO, Three Genes Involved in the Remodeling of Brucella Cell Envelope
por: Conde-Álvarez, Raquel, et al.
Publicado: (2018)

The nucleotide-binding site of Aquifex aeolicus LpxC
por: Buetow, Lori, et al.
Publicado: (2006)

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis
por: Mostafavi, Mina, et al.
Publicado: (2018)

Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa
por: Jacewicz, Agata, et al.
Publicado: (2016)

The Crystal Structure of L-Leucine Dehydrogenase from Pseudomonas aeruginosa
por: Kim, Seheon, et al.
Publicado: (2022)

Prediction of the Closed Conformation and Insights into the Mechanism of the Membrane Enzyme LpxR
por: Saunders, Graham M., et al.
Publicado: (2018)

Regulated Expression of lpxC Allows for Reduction of Endotoxicity in Bordetella pertussis
por: Pérez-Ortega, Jesús, et al.
Publicado: (2022)

Molecular Basis of Essentiality of Early Critical Steps in the Lipopolysaccharide Biogenesis in Escherichia coli K-12: Requirement of MsbA, Cardiolipin, LpxL, LpxM and GcvB
por: Gorzelak, Patrycja, et al.
Publicado: (2021)

FolX from Pseudomonas aeruginosa is octameric in both crystal and solution
por: Gabrielsen, Mads, et al.
Publicado: (2012)

Detection of Lipoprotein X (LpX): A challenge in patients with severe hypercholesterolaemia
por: Ćwiklińska, Agnieszka, et al.
Publicado: (2020)

When LDL Cholesterol Is Not LDL Cholesterol: LpX, A Clinical Lesson
por: Huygen, Lisa P.M., et al.
Publicado: (2022)

Machine learning approaches to study the structure-activity relationships of LpxC inhibitors
por: Yu, Tianshi, et al.
Publicado: (2023)

UDP-xylose and UDP-galactose synthesis in Trichomonas vaginalis
por: Rosenberger, Andrea F.N., et al.
Publicado: (2012)

Biosynthesis of UDP-xylose and UDP-arabinose in Sinorhizobium meliloti 1021: first characterization of a bacterial UDP-xylose synthase, and UDP-xylose 4-epimerase
por: Gu, Xiaogang, et al.
Publicado: (2011)

Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo
por: Ferjani, Ali, et al.
Publicado: (2018)

Resistance of Pseudomonas Aeruginosa
por: Graevenitz, Alexander Von
Publicado: (1977)

Pseudomonas aeruginosa Biofilms
por: Thi, Minh Tam Tran, et al.
Publicado: (2020)

Extragenic suppressor mutations in ΔripA disrupt stability and function of LpxA
por: Miller, Cheryl N, et al.
Publicado: (2014)

Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011
por: Cram, Erik D., et al.
Publicado: (2017)

Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane
por: Cotrim, Camila A., et al.
Publicado: (2018)

The prevalence of Pseudomonas aeruginosa and multidrug resistant Pseudomonas aeruginosa in healthy captive ophidian
por: Sala, Andrea, et al.
Publicado: (2019)

Vitamin C inhibits crystallization of struvite from artificial urine in the presence of Pseudomonas aeruginosa
por: Manzoor, Muhammed A. P., et al.
Publicado: (2018)

Facile and Stereo-Selective Synthesis of UDP-α-D-xylose and UDP-β-L-arabinose Using UDP-Sugar Pyrophosphorylase
por: Wang, JiaJia, et al.
Publicado: (2018)

Biofilm assembly becomes crystal clear – filamentous bacteriophage organize the Pseudomonas aeruginosa biofilm matrix into a liquid crystal
por: Secor, Patrick R., et al.
Publicado: (2015)

The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation
por: Khodaparast, Laleh, et al.
Publicado: (2016)

New virulence factor CSK29544_02616 as LpxA binding partner in Cronobacter sakazakii
por: Kim, Seongok, et al.
Publicado: (2018)

An Essential Membrane Protein Modulates the Proteolysis of LpxC to Control Lipopolysaccharide Synthesis in Escherichia coli
por: Fivenson, Elayne M., et al.
Publicado: (2020)

A New Factor LapD Is Required for the Regulation of LpxC Amounts and Lipopolysaccharide Trafficking
por: Wieczorek, Alicja, et al.
Publicado: (2022)

Community-acquired, hospital-acquired, and healthcare-associated pneumonia caused by Pseudomonas aeruginosa
por: Fujii, Ayumi, et al.
Publicado: (2014)

Author Correction: Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo
por: Ferjani, Ali, et al.
Publicado: (2019)

Crystal structure of UDP-glucose:anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea
por: Hiromoto, Takeshi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7aoavtul6fg67mv7i9k84b18pi