Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias

Collapsin response mediator protein-2 (CRMP2) regulates axonal growth cone extension, and increased CRMP2 phosphorylation may lead to axonal degeneration. Axonal and synaptic pathology is an important feature of Lewy body dementias (LBD), but the state of CRMP2 phosphorylation (pCRMP2) as well as it...

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Detalles Bibliográficos
Autores principales: Xing, Huayang, Lim, Yun-An, Chong, Joyce R., Lee, Jasinda H., Aarsland, Dag, Ballard, Clive G., Francis, Paul T., Chen, Christopher P., Lai, Mitchell K. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016931/
https://www.ncbi.nlm.nih.gov/pubmed/27609071
http://dx.doi.org/10.1186/s13041-016-0264-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016931/
https://www.ncbi.nlm.nih.gov/pubmed/27609071
http://dx.doi.org/10.1186/s13041-016-0264-9

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