Cargando…
Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
Collapsin response mediator protein-2 (CRMP2) regulates axonal growth cone extension, and increased CRMP2 phosphorylation may lead to axonal degeneration. Axonal and synaptic pathology is an important feature of Lewy body dementias (LBD), but the state of CRMP2 phosphorylation (pCRMP2) as well as it...
Autores principales: | Xing, Huayang, Lim, Yun-An, Chong, Joyce R., Lee, Jasinda H., Aarsland, Dag, Ballard, Clive G., Francis, Paul T., Chen, Christopher P., Lai, Mitchell K. P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016931/ https://www.ncbi.nlm.nih.gov/pubmed/27609071 http://dx.doi.org/10.1186/s13041-016-0264-9 |
Ejemplares similares
-
Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer’s disease but not Lewy body dementias
por: Chai, Yuek Ling, et al.
Publicado: (2023) -
Decreased DHA‐containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ(42), phosphorylated α‐synuclein, and synaptopathology
por: Chong, Joyce R., et al.
Publicado: (2023) -
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers
por: Gibson, Lucy L., et al.
Publicado: (2023) -
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias
por: Howlett, David R., et al.
Publicado: (2014) -
Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study
por: Stubendorff, Kajsa, et al.
Publicado: (2014)