Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies

HGF-Met signaling contributes to various biological events by controlling cell migration. Since the abnormal activation of Met receptor causes cancer progression, inhibitors such as neutralizing antibodies are regarded as promising therapeutics. HGF is secreted as a single-chain (sc) precursor and i...

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Detalles Bibliográficos
Autores principales: Umitsu, Masataka, Sakai, Katsuya, Ogasawara, Satoshi, Kaneko, Mika K., Asaki, Ryoko, Tamura-Kawakami, Keiko, Kato, Yukinari, Matsumoto, Kunio, Takagi, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017023/
https://www.ncbi.nlm.nih.gov/pubmed/27608665
http://dx.doi.org/10.1038/srep33149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017023/
https://www.ncbi.nlm.nih.gov/pubmed/27608665
http://dx.doi.org/10.1038/srep33149

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