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Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies
HGF-Met signaling contributes to various biological events by controlling cell migration. Since the abnormal activation of Met receptor causes cancer progression, inhibitors such as neutralizing antibodies are regarded as promising therapeutics. HGF is secreted as a single-chain (sc) precursor and i...
Autores principales: | Umitsu, Masataka, Sakai, Katsuya, Ogasawara, Satoshi, Kaneko, Mika K., Asaki, Ryoko, Tamura-Kawakami, Keiko, Kato, Yukinari, Matsumoto, Kunio, Takagi, Junichi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017023/ https://www.ncbi.nlm.nih.gov/pubmed/27608665 http://dx.doi.org/10.1038/srep33149 |
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