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Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress

Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2–3 cm are plagued with high local recurrence rates and overall survival of these patients remains poor. Currently no adjuvant therapies e...

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Detalles Bibliográficos
Autores principales: Thompson, Scott M., Callstrom, Matthew R., Jondal, Danielle E., Butters, Kim A., Knudsen, Bruce E., Anderson, Jill L., Lien, Karen R., Sutor, Shari L., Lee, Ju-Seog, Thorgeirsson, Snorri S., Grande, Joseph P., Roberts, Lewis R., Woodrum, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017586/
https://www.ncbi.nlm.nih.gov/pubmed/27611696
http://dx.doi.org/10.1371/journal.pone.0162634