A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration

We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we present a novel MDH2 inhibitor compound 7 containing b...

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Detalles Bibliográficos
Autores principales: Ban, Hyun Seung, Xu, Xuezhen, Jang, Kusik, Kim, Inhyub, Kim, Bo-Kyung, Lee, Kyeong, Won, Misun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017629/
https://www.ncbi.nlm.nih.gov/pubmed/27611801
http://dx.doi.org/10.1371/journal.pone.0162568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017629/
https://www.ncbi.nlm.nih.gov/pubmed/27611801
http://dx.doi.org/10.1371/journal.pone.0162568

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