Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-repeat expansion in the huntingtin protein. Activation of the kynurenine pathway of tryptophan degradation is implicated in the pathogenesis of HD. Indoleamine-2,3-dioxygenase (IDO) catalyzes the oxi...

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Detalles Bibliográficos
Autores principales: Donley, David W., Olson, Andrew R., Raisbeck, Merl F., Fox, Jonathan H., Gigley, Jason P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017698/
https://www.ncbi.nlm.nih.gov/pubmed/27611938
http://dx.doi.org/10.1371/journal.pone.0162404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017698/
https://www.ncbi.nlm.nih.gov/pubmed/27611938
http://dx.doi.org/10.1371/journal.pone.0162404

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