Quantitation of Murine Stroma and Selective Purification of the Human Tumor Component of Patient-Derived Xenografts for Genomic Analysis

Patient-derived xenograft (PDX) mouse models are increasingly used for preclinical therapeutic testing of human cancer. A limitation in molecular and genetic characterization of PDX tumors is the presence of integral murine stroma. This is particularly problematic for genomic sequencing of PDX model...

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Detalles Bibliográficos
Autores principales: Schneeberger, Valentina E., Allaj, Viola, Gardner, Eric E., Poirier, J. T., Rudin, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017757/
https://www.ncbi.nlm.nih.gov/pubmed/27611664
http://dx.doi.org/10.1371/journal.pone.0160587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017757/
https://www.ncbi.nlm.nih.gov/pubmed/27611664
http://dx.doi.org/10.1371/journal.pone.0160587

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