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Quantitation of Murine Stroma and Selective Purification of the Human Tumor Component of Patient-Derived Xenografts for Genomic Analysis

Patient-derived xenograft (PDX) mouse models are increasingly used for preclinical therapeutic testing of human cancer. A limitation in molecular and genetic characterization of PDX tumors is the presence of integral murine stroma. This is particularly problematic for genomic sequencing of PDX model...

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Detalles Bibliográficos
Autores principales:	Schneeberger, Valentina E., Allaj, Viola, Gardner, Eric E., Poirier, J. T., Rudin, Charles M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017757/ https://www.ncbi.nlm.nih.gov/pubmed/27611664 http://dx.doi.org/10.1371/journal.pone.0160587

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