The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2

Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors. RX-3117 is activated by uridine-cytidine kinase (UCK). Since UCK exist...

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Detalles Bibliográficos
Autores principales: Sarkisjan, Dzjemma, Julsing, Joris R., Smid, Kees, de Klerk, Daniël, van Kuilenburg, André B. P., Meinsma, Rutger, Lee, Young B., Kim, Deog J., Peters, Godefridus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017758/
https://www.ncbi.nlm.nih.gov/pubmed/27612203
http://dx.doi.org/10.1371/journal.pone.0162901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017758/
https://www.ncbi.nlm.nih.gov/pubmed/27612203
http://dx.doi.org/10.1371/journal.pone.0162901

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