Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research. We report on the discovery of two classes of noncovalent inhibitors displaying unique structural feat...

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Detalles Bibliográficos
Autores principales: Speranzini, Valentina, Rotili, Dante, Ciossani, Giuseppe, Pilotto, Simona, Marrocco, Biagina, Forgione, Mariantonietta, Lucidi, Alessia, Forneris, Federico, Mehdipour, Parinaz, Velankar, Sameer, Mai, Antonello, Mattevi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017823/
https://www.ncbi.nlm.nih.gov/pubmed/27626075
http://dx.doi.org/10.1126/sciadv.1601017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017823/
https://www.ncbi.nlm.nih.gov/pubmed/27626075
http://dx.doi.org/10.1126/sciadv.1601017

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