MRI characteristics of proctitis in Crohn’s disease on perianal MRI

PURPOSE: Multiple features have been described for assessing inflammation in Crohn’s disease (CD) in MR enterography, but have not been validated in perianal magnetic resonance imaging (MRI). Retrospectively, we studied which MRI features are valuable in assessing proctitis. MATERIALS AND METHODS: C...

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Autores principales: Tutein Nolthenius, Charlotte J., Bipat, Shandra, Mearadji, Banafsche, Spijkerboer, Anje M., Ponsioen, Cyriel Y., Montauban van Swijndregt, Alexander D., Stoker, Jaap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018025/
https://www.ncbi.nlm.nih.gov/pubmed/27315072
http://dx.doi.org/10.1007/s00261-016-0802-z
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author Tutein Nolthenius, Charlotte J.
Bipat, Shandra
Mearadji, Banafsche
Spijkerboer, Anje M.
Ponsioen, Cyriel Y.
Montauban van Swijndregt, Alexander D.
Stoker, Jaap
author_facet Tutein Nolthenius, Charlotte J.
Bipat, Shandra
Mearadji, Banafsche
Spijkerboer, Anje M.
Ponsioen, Cyriel Y.
Montauban van Swijndregt, Alexander D.
Stoker, Jaap
author_sort Tutein Nolthenius, Charlotte J.
collection PubMed
description PURPOSE: Multiple features have been described for assessing inflammation in Crohn’s disease (CD) in MR enterography, but have not been validated in perianal magnetic resonance imaging (MRI). Retrospectively, we studied which MRI features are valuable in assessing proctitis. MATERIALS AND METHODS: CD patients (≥18 years) who underwent colonoscopy (reference standard) and perianal fistula MRI within 8 weeks were included. Seventeen MRI features were blindly scored by three observers and correlated to endoscopy (regression analysis). Reproducibility (multirater kappa, intraclass correlation coefficient) was determined for all three observer pairs. MRI features were considered relevant when significantly correlated to endoscopy for ≥2 observers, and reproducibility was ≥0.40 for ≥2 observer pairs. RESULTS: Perianal MRI of 58 CD patients were included. Wall thickness, rectal mural fat, creeping fat, and size of mesorectal lymph nodes showed a significant correlation with endoscopy for ≥2 observers (p = 0.000–0.023, p = 0.011–0.172, p = 0.007–0.011 and p = 0.000–0.005, respectively) with a kappa/intraclass correlation coefficient of ≥0.60 for ≥2 observer pairs. Perimural T2 signal and perimural enhancement significantly correlated to endoscopy (all p values ≤0.05) for all three observers and the reproducibility was ≥0.40 for ≥2 observer pairs. Mural T2 signal and degree and pattern of T1 enhancement showed significant correlation to endoscopy for two observers, but with poor to moderate reproducibility. CONCLUSION: Wall thickness, mural fat, and mesorectal features (perimural T2 signal, perimural enhancement, creeping fat, and size of mesorectal lymph nodes) had significant correlation to endoscopy and were reproducible in diagnosing proctitis. Some established luminal features in MRE were considered not useful.
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spelling pubmed-50180252016-09-20 MRI characteristics of proctitis in Crohn’s disease on perianal MRI Tutein Nolthenius, Charlotte J. Bipat, Shandra Mearadji, Banafsche Spijkerboer, Anje M. Ponsioen, Cyriel Y. Montauban van Swijndregt, Alexander D. Stoker, Jaap Abdom Radiol (NY) Article PURPOSE: Multiple features have been described for assessing inflammation in Crohn’s disease (CD) in MR enterography, but have not been validated in perianal magnetic resonance imaging (MRI). Retrospectively, we studied which MRI features are valuable in assessing proctitis. MATERIALS AND METHODS: CD patients (≥18 years) who underwent colonoscopy (reference standard) and perianal fistula MRI within 8 weeks were included. Seventeen MRI features were blindly scored by three observers and correlated to endoscopy (regression analysis). Reproducibility (multirater kappa, intraclass correlation coefficient) was determined for all three observer pairs. MRI features were considered relevant when significantly correlated to endoscopy for ≥2 observers, and reproducibility was ≥0.40 for ≥2 observer pairs. RESULTS: Perianal MRI of 58 CD patients were included. Wall thickness, rectal mural fat, creeping fat, and size of mesorectal lymph nodes showed a significant correlation with endoscopy for ≥2 observers (p = 0.000–0.023, p = 0.011–0.172, p = 0.007–0.011 and p = 0.000–0.005, respectively) with a kappa/intraclass correlation coefficient of ≥0.60 for ≥2 observer pairs. Perimural T2 signal and perimural enhancement significantly correlated to endoscopy (all p values ≤0.05) for all three observers and the reproducibility was ≥0.40 for ≥2 observer pairs. Mural T2 signal and degree and pattern of T1 enhancement showed significant correlation to endoscopy for two observers, but with poor to moderate reproducibility. CONCLUSION: Wall thickness, mural fat, and mesorectal features (perimural T2 signal, perimural enhancement, creeping fat, and size of mesorectal lymph nodes) had significant correlation to endoscopy and were reproducible in diagnosing proctitis. Some established luminal features in MRE were considered not useful. Springer US 2016-06-17 2016 /pmc/articles/PMC5018025/ /pubmed/27315072 http://dx.doi.org/10.1007/s00261-016-0802-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Tutein Nolthenius, Charlotte J.
Bipat, Shandra
Mearadji, Banafsche
Spijkerboer, Anje M.
Ponsioen, Cyriel Y.
Montauban van Swijndregt, Alexander D.
Stoker, Jaap
MRI characteristics of proctitis in Crohn’s disease on perianal MRI
title MRI characteristics of proctitis in Crohn’s disease on perianal MRI
title_full MRI characteristics of proctitis in Crohn’s disease on perianal MRI
title_fullStr MRI characteristics of proctitis in Crohn’s disease on perianal MRI
title_full_unstemmed MRI characteristics of proctitis in Crohn’s disease on perianal MRI
title_short MRI characteristics of proctitis in Crohn’s disease on perianal MRI
title_sort mri characteristics of proctitis in crohn’s disease on perianal mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018025/
https://www.ncbi.nlm.nih.gov/pubmed/27315072
http://dx.doi.org/10.1007/s00261-016-0802-z
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