Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition

Treatment of acute liver failure by cell transplantation is hindered by a shortage of human hepatocytes. Current protocols for hepatic differentiation of human induced pluripotent stem cells (hiPSCs) result in low yields, cellular heterogeneity, and limited scalability. In the present study, we have...

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Detalles Bibliográficos
Autores principales: Pettinato, Giuseppe, Ramanathan, Rajesh, Fisher, Robert A, Mangino, Martin J., Zhang, Ning, Wen, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018737/
https://www.ncbi.nlm.nih.gov/pubmed/27616299
http://dx.doi.org/10.1038/srep32888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018737/
https://www.ncbi.nlm.nih.gov/pubmed/27616299
http://dx.doi.org/10.1038/srep32888

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