An Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase

The formation of well-defined filamentous amyloid structures involves a polydisperse collection of oligomeric states for which relatively little is known in terms of structural organization. Here we use extensive, unbiased explicit solvent molecular dynamics (MD) simulations to investigate the struc...

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Detalles Bibliográficos
Autores principales: Matthes, Dirk, Gapsys, Vytautas, Brennecke, Julian T., de Groot, Bert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018807/
https://www.ncbi.nlm.nih.gov/pubmed/27616019
http://dx.doi.org/10.1038/srep33156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018807/
https://www.ncbi.nlm.nih.gov/pubmed/27616019
http://dx.doi.org/10.1038/srep33156

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