Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions

Accumulating evidence implies that both AKT1 and GABA(A) receptor (GABA(A)R) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABA(A)R expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAerg...

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Detalles Bibliográficos
Autores principales: Chang, Chia-Yuan, Chen, Yi-Wen, Wang, Tsu-Wei, Lai, Wen-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018883/
https://www.ncbi.nlm.nih.gov/pubmed/27615800
http://dx.doi.org/10.1038/srep33095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018883/
https://www.ncbi.nlm.nih.gov/pubmed/27615800
http://dx.doi.org/10.1038/srep33095

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