Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly

The exon junction complex (EJC) is an RNA binding complex comprised of the core components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause neurodevelopmental pathologies. Further, mice heterozygous for either Magoh or Rbm8a exhibit aberrant neurogenesis and microcephaly. Yet despit...

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Detalles Bibliográficos
Autores principales: Mao, Hanqian, McMahon, John J., Tsai, Yi-Hsuan, Wang, Zefeng, Silver, Debra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019403/
https://www.ncbi.nlm.nih.gov/pubmed/27618312
http://dx.doi.org/10.1371/journal.pgen.1006282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019403/
https://www.ncbi.nlm.nih.gov/pubmed/27618312
http://dx.doi.org/10.1371/journal.pgen.1006282

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