Cargando…
Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly
The exon junction complex (EJC) is an RNA binding complex comprised of the core components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause neurodevelopmental pathologies. Further, mice heterozygous for either Magoh or Rbm8a exhibit aberrant neurogenesis and microcephaly. Yet despit...
Autores principales: | Mao, Hanqian, McMahon, John J., Tsai, Yi-Hsuan, Wang, Zefeng, Silver, Debra L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019403/ https://www.ncbi.nlm.nih.gov/pubmed/27618312 http://dx.doi.org/10.1371/journal.pgen.1006282 |
Ejemplares similares
-
Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex
por: Mao, Hanqian, et al.
Publicado: (2017) -
Perispeckles are major assembly sites for the exon junction core complex
por: Daguenet, Elisabeth, et al.
Publicado: (2012) -
A Case of Microcephaly Following Embryonic Roentgen Irradiation
Publicado: (1930) -
The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus
por: Shohayeb, Belal, et al.
Publicado: (2020) -
JuncDB: an exon–exon junction database
por: Chorev, Michal, et al.
Publicado: (2016)