Cargando…

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

AIMS: Changes in the islet vasculature have been implicated in the regulation of β-cell survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to compensate for the increased insulin demand in obesity eventually leads to diabetes; as a result of the complex inte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shah, Payal, Lueschen, Navina, Ardestani, Amin, Oberholzer, Jose, Olerud, Johan, Carlsson, Per-Ola, Maedler, Kathrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019443/ https://www.ncbi.nlm.nih.gov/pubmed/27617438 http://dx.doi.org/10.1371/journal.pone.0161834

Ejemplares similares

Correction: Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes
por: Shah, Payal, et al.
Publicado: (2023)

Increased Numbers of Low-Oxygenated Pancreatic Islets After Intraportal Islet Transplantation
por: Olsson, Richard, et al.
Publicado: (2011)

Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice
por: Drott, Carl Johan, et al.
Publicado: (2012)

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
por: Olerud, Johan, et al.
Publicado: (2008)

Angiopoetin-like 4 in sickle cell retinopathy
por: Leitão Guerra, Ricardo Luz, et al.
Publicado: (2018)

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
por: Olerud, Johan, et al.
Publicado: (2011)

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
por: Ardestani, Amin, et al.
Publicado: (2020)

mTORC in β cells: more Than Only Recognizing Comestibles
por: Maedler, Kathrin, et al.
Publicado: (2017)

MST1 deletion protects β-cells in a mouse model of diabetes
por: Ardestani, Amin, et al.
Publicado: (2022)

Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy
por: Ardestani, Amin, et al.
Publicado: (2021)

Case Report: Neratinib Therapy Improves Glycemic Control in a Patient With Type 2 Diabetes and Breast Cancer
por: Angelis, Vasileios, et al.
Publicado: (2022)

Irisin—A Pancreatic Islet Hormone
por: Norman, Daniel, et al.
Publicado: (2022)

Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11
por: Shu, Luan, et al.
Publicado: (2017)

SARS-CoV-2 and pancreas: a potential pathological interaction?
por: Geravandi, Shirin, et al.
Publicado: (2021)

Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy
por: Shlamkovich, Tomer, et al.
Publicado: (2017)

GLP-2 Is Locally Produced From Human Islets and Balances Inflammation Through an Inter-Islet-Immune Cell Crosstalk
por: He, Wei, et al.
Publicado: (2021)

Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes
por: Ardestani, Amin, et al.
Publicado: (2019)

PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes
por: Lupse, Blaz, et al.
Publicado: (2022)

Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass
por: Agudo, Judith, et al.
Publicado: (2012)

Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization
por: Henriksnäs, Johanna, et al.
Publicado: (2012)

FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization
por: Kikuchi, Osamu, et al.
Publicado: (2012)

Macrophage-associated pro-inflammatory state in human islets from obese individuals
por: He, Wei, et al.
Publicado: (2019)

Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours
por: Coutelle, O, et al.
Publicado: (2015)

Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer
por: Hohendorff, Jerzy, et al.
Publicado: (2019)

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
por: Carlsson, Per‐Ola, et al.
Publicado: (2018)

Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice
por: Liljebäck, Hanna, et al.
Publicado: (2019)

Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
por: Espes, Daniel, et al.
Publicado: (2011)

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells
por: Olsson, Richard, et al.
Publicado: (2011)

MST1 is a novel regulator of apoptosis in pancreatic beta-cells
por: Ardestani, Amin, et al.
Publicado: (2014)

Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets
por: Ullsten, Sara, et al.
Publicado: (2017)

Bioengineering with Endothelial Progenitor Cells Improves the Vascular Engraftment of Transplanted Human Islets
por: Grapensparr, Liza, et al.
Publicado: (2018)

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement
por: Liljebäck, Hanna, et al.
Publicado: (2019)

Alveolar Soft Part Sarcoma Presenting as Hypervascular Adrenal Metastasis
por: Goroshi, Manjunath, et al.
Publicado: (2018)

Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to That in Native Islets
por: Christoffersson, Gustaf, et al.
Publicado: (2010)

Ileal malignant hemangioendothelioma as a hypervascular lesion on computed tomography scan()
por: Li, Hang, et al.
Publicado: (2013)

Decreased β-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets
por: Ullsten, Sara, et al.
Publicado: (2019)

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2
por: Yuan, T, et al.
Publicado: (2016)

Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy
por: Wang, Mingyang, et al.
Publicado: (2023)

An SCF(FBXO28) E3 Ligase Protects Pancreatic β-Cells from Apoptosis
por: Gorrepati, Kanaka Durga Devi, et al.
Publicado: (2018)

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response
por: Gorrepati, Kanaka Durga Devi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gumbjlm7aq2omt2j5afm7onb7l