Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

Evolution has often copied and repurposed the mitogen-activated protein kinase (MAPK) signaling module. Understanding how connections form during evolution, in disease and across individuals requires knowledge of the basic tenets that govern kinase-substrate interactions. We identify criteria suffic...

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Detalles Bibliográficos
Autores principales: Groves, Benjamin, Khakhar, Arjun, Nadel, Cory M, Gardner, Richard G, Seelig, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019841/
https://www.ncbi.nlm.nih.gov/pubmed/27525484
http://dx.doi.org/10.7554/eLife.15200