Cargando…

A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease

Amyotrophic lateral sclerosis (ALS) is an aggressive multifactorial disease converging on a common pathology: the degeneration of motor neurons (MNs), their axons and neuromuscular synapses. This vulnerability and dysfunction of MNs highlights the dependency of these large cells on their intracellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clark, Jayden A., Yeaman, Elise J., Blizzard, Catherine A., Chuckowree, Jyoti A., Dickson, Tracey C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020100/ https://www.ncbi.nlm.nih.gov/pubmed/27679561 http://dx.doi.org/10.3389/fncel.2016.00204

Ejemplares similares

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity
por: Blizzard, Catherine A., et al.
Publicado: (2015)

The Microtubule-Modulating Drug Epothilone D Alters Dendritic Spine Morphology in a Mouse Model of Mild Traumatic Brain Injury
por: Chuckowree, Jyoti A., et al.
Publicado: (2018)

Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?
por: Clark, Jayden, et al.
Publicado: (2020)

Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis
por: Clark, Rosemary M., et al.
Publicado: (2018)

Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43(A315T) Mouse Model of Amyotrophic Lateral Sclerosis
por: Handley, Emily E., et al.
Publicado: (2022)

Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro
por: Clark, J. A., et al.
Publicado: (2020)

Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function
por: Jiang, Tongcui, et al.
Publicado: (2019)

Basal ganglia alterations in amyotrophic lateral sclerosis
por: Castelnovo, Veronica, et al.
Publicado: (2023)

Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis
por: Cozzolino, Mauro, et al.
Publicado: (2015)

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis
por: Alvia, Marcela, et al.
Publicado: (2022)

Static and dynamic alterations in the amplitude of low-frequency fluctuation in patients with amyotrophic lateral sclerosis
por: Ma, Xujing, et al.
Publicado: (2020)

The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis
por: Pradhan, Jonu, et al.
Publicado: (2019)

Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model
por: Fogarty, Matthew J., et al.
Publicado: (2017)

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Abramzon, Yevgeniya A., et al.
Publicado: (2020)

Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis
por: Bowerman, Melissa, et al.
Publicado: (2013)

Motoneuron firing in amyotrophic lateral sclerosis (ALS)
por: de Carvalho, Mamede, et al.
Publicado: (2014)

Miro1 deficiency in amyotrophic lateral sclerosis
por: Zhang, Fan, et al.
Publicado: (2015)

Laryngeal Sensitivity in Patients with Amyotrophic Lateral Sclerosis
por: Ruoppolo, Giovanni, et al.
Publicado: (2016)

Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis
por: Ferrara, Deborah, et al.
Publicado: (2018)

Potential Preventive Strategies for Amyotrophic Lateral Sclerosis
por: Kuraszkiewicz, B., et al.
Publicado: (2020)

Stress Granule Dysregulation in Amyotrophic Lateral Sclerosis
por: Dudman, Jessica, et al.
Publicado: (2020)

Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
por: Nijssen, Jik, et al.
Publicado: (2017)

Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis
por: Broadhead, Matthew J., et al.
Publicado: (2022)

Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis
por: Devine, Matthew S., et al.
Publicado: (2015)

Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice
por: Clark, Rosemary M., et al.
Publicado: (2023)

Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis
por: D’Ambrosi, Nadia, et al.
Publicado: (2014)

Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis
por: Baldaranov, Dobri, et al.
Publicado: (2017)

Structural Connectivity Alterations in Amyotrophic Lateral Sclerosis: A Graph Theory Based Imaging Study
por: Fortanier, Etienne, et al.
Publicado: (2019)

Amyotrophic lateral sclerosis: a dying motor unit?
por: Piotrkiewicz, Maria, et al.
Publicado: (2013)

Are There Modifiable Environmental Factors Related to Amyotrophic Lateral Sclerosis?
por: Kuraszkiewicz, Bozenna, et al.
Publicado: (2018)

Abnormal Functional Connectivity Density in Amyotrophic Lateral Sclerosis
por: Li, Weina, et al.
Publicado: (2018)

Unraveling the Complexity of Amyotrophic Lateral Sclerosis Survival Prediction
por: Pfohl, Stephen R., et al.
Publicado: (2018)

Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?
por: Xue, Yuan Chao, et al.
Publicado: (2018)

Taxonomy Meets Neurology, the Case of Amyotrophic Lateral Sclerosis
por: Morello, Giovanna, et al.
Publicado: (2018)

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
por: Webster, Christopher P., et al.
Publicado: (2017)

Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
por: Ranganathan, Ramya, et al.
Publicado: (2020)

Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis
por: Xue, Yuan Chao, et al.
Publicado: (2020)

Kynurenine Pathway Metabolites as Biomarkers for Amyotrophic Lateral Sclerosis
por: Tan, Vanessa X., et al.
Publicado: (2019)

The Potential for Transition Metal-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
por: Lovejoy, David B., et al.
Publicado: (2014)

Differences in Dysfunction of Thenar and Hypothenar Motoneurons in Amyotrophic Lateral Sclerosis
por: Fang, Jia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0pe1t7fd8d7kmjk40erd7tko18