The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5

G protein-coupled receptor kinase 5 (GRK5) is a regulator of cardiac performance and a potential therapeutic target in heart failure in the adult. Additionally, we have previously classified GRK5 as a determinant of left-right asymmetry and proper heart development using zebrafish. We thus aimed to...

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Detalles Bibliográficos
Autores principales: Lessel, Davor, Muhammad, Tariq, Casar Tena, Teresa, Moepps, Barbara, Burkhalter, Martin D., Hitz, Marc-Phillip, Toka, Okan, Rentzsch, Axel, Schubert, Stephan, Schalinski, Adelheid, Bauer, Ulrike M. M., Kubisch, Christian, Ware, Stephanie M., Philipp, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020398/
https://www.ncbi.nlm.nih.gov/pubmed/27618959
http://dx.doi.org/10.1038/srep33231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020398/
https://www.ncbi.nlm.nih.gov/pubmed/27618959
http://dx.doi.org/10.1038/srep33231

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