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Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury

Acute kidney injury (AKI) is a rapid loss of kidney function characterized by damage to renal tubular cells driven by mitochondrial dysregulation and oxidative stress. Here, we used a murine caecal ligation and puncture (CLP) model of sepsis-induced AKI to study the role of sirtuin 3 (SIRT3), a NAD(...

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Detalles Bibliográficos
Autores principales: Zhao, Wen-Yu, Zhang, Lei, Sui, Ming-Xing, Zhu, You-Hua, Zeng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020492/
https://www.ncbi.nlm.nih.gov/pubmed/27620507
http://dx.doi.org/10.1038/srep33201