Targeting Motor End Plates for Delivery of Adenoviruses: An Approach to Maximize Uptake and Transduction of Spinal Cord Motor Neurons

Gene therapy can take advantage of the skeletal muscles/motor neurons anatomical relationship to restrict gene expression to the spinal cord ventral horn. Furthermore, recombinant adenoviruses are attractive viral-vectors as they permit spatial and temporal modulation of transgene expression. In the...

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Detalles Bibliográficos
Autores principales: Tosolini, Andrew Paul, Morris, Renée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020496/
https://www.ncbi.nlm.nih.gov/pubmed/27619631
http://dx.doi.org/10.1038/srep33058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020496/
https://www.ncbi.nlm.nih.gov/pubmed/27619631
http://dx.doi.org/10.1038/srep33058

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