Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation limits the progression of DN. Activation of PAR-1 in fibroblast-like cells, however, induces proliferation and extracellul...

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Detalles Bibliográficos
Autores principales: Waasdorp, Maaike, Duitman, JanWillem, Florquin, Sandrine, Spek, C. Arnold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020504/
https://www.ncbi.nlm.nih.gov/pubmed/27618774
http://dx.doi.org/10.1038/srep33030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020504/
https://www.ncbi.nlm.nih.gov/pubmed/27618774
http://dx.doi.org/10.1038/srep33030

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