A systematic review and meta‐analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

BACKGROUND: The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for the development of gene therapy in glioma. We tested the hypothesis that this is because of limitations in the internal and external validity...

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Detalles Bibliográficos
Autores principales: Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson McLean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S., Whittle, I. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Systematic Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020579/
https://www.ncbi.nlm.nih.gov/pubmed/27668084
http://dx.doi.org/10.1002/ebm2.6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020579/
https://www.ncbi.nlm.nih.gov/pubmed/27668084
http://dx.doi.org/10.1002/ebm2.6

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