Cargando…

A systematic review and meta‐analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

BACKGROUND: The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for the development of gene therapy in glioma. We tested the hypothesis that this is because of limitations in the internal and external validity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson McLean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S., Whittle, I. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2014
Materias:	Systematic Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020579/ https://www.ncbi.nlm.nih.gov/pubmed/27668084 http://dx.doi.org/10.1002/ebm2.6

Ejemplares similares

Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?
por: Hirst, T C, et al.
Publicado: (2013)

From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models
por: Egan, K.J., et al.
Publicado: (2016)

Study protocol – A systematic review and meta‐analysis of hypothermia in experimental traumatic brain injury: Why have promising animal studies not been replicated in pragmatic clinical trials?
por: Hirst, Theodore C., et al.
Publicado: (2016)

Making the most of animal data – improving the prospect of success in pragmatic trials in the neurosciences
por: Egan, Kieren J, et al.
Publicado: (2011)

Oxidative Stress in Alzheimer's Disease: Why Did Antioxidant Therapy Fail?
por: Persson, Torbjörn, et al.
Publicado: (2014)

Evidence synthesis in trial design: an example from the neurosciences
por: Egan, Kieren, et al.
Publicado: (2013)

A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models
por: Jue, Toni Rose, et al.
Publicado: (2018)

Why Did He Say This?
Publicado: (1898)

The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease
por: Egan, K. J., et al.
Publicado: (2015)

Why did doctrinal religions first appear in the Northern Subtropical Zone?
por: Dunbar, R.I.M.
Publicado: (2023)

Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
por: Macleod, Malcolm R., et al.
Publicado: (2015)

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
por: Macleod, Malcolm R., et al.
Publicado: (2015)

DIPG-22. TRIPTOLIDE AS A POTENTIALLY PROMISING THERAPY FOR DIFFUSE MIDLINE GLIOMA
por: Ciani, Ludovica, et al.
Publicado: (2023)

The Challenges and the Promise of Molecular Targeted Therapy in Malignant Gliomas()
por: Wang, Hongxiang, et al.
Publicado: (2015)

Why Did the FDA Approve These Advertisements?
por: Oaks, David
Publicado: (2006)

Why Did America Declare War?
Publicado: (1918)

Guided imagery relaxation therapy on preoperative anxiety: why did the authors omit pain data?
por: Gray, Richard, et al.
Publicado: (2020)

Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy
por: Meirelles, Lyvia Eloiza de Freitas, et al.
Publicado: (2023)

Resveratrol: Why Is It a Promising Therapy for Chronic Kidney Disease Patients?
por: Saldanha, Juliana F., et al.
Publicado: (2013)

Martian outflow channels: How did their source aquifers form, and why did they drain so rapidly?
por: Rodriguez, J. Alexis P., et al.
Publicado: (2015)

Hereford and Cholera — Why Did We Escape It?
por: Ross, John
Publicado: (1990)

Care trajectories of surgically treated patients with a prolactinoma: why did they opt for surgery?
por: van Trigt, Victoria R., et al.
Publicado: (2023)

Treatment of Gliomas: How did we get here?
por: Chowdhary, Michelle M., et al.
Publicado: (2015)

Social media, body image and food choices in healthy young adults: A mixed methods systematic review
por: Rounsefell, Kim, et al.
Publicado: (2019)

Erratum: Martian outflow channels: How did their source aquifers form, and why did they drain so rapidly?
por: Rodriguez, J. Alexis P., et al.
Publicado: (2015)

Correction: Care trajectories of surgically treated patients with a prolactinoma: why did they opt for surgery?
por: van Trigt, Victoria R., et al.
Publicado: (2023)

Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies
por: Carvalho da Fonseca, Anna Carolina, et al.
Publicado: (2013)

Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma
por: An, Ya-Wen, et al.
Publicado: (2020)

EPAC2: A new and promising protein for glioma pathogenesis and therapy
por: Richard, Seidu A.
Publicado: (2020)

Why Was the 2009 Influenza Pandemic in England So Small?
por: Kubiak, Ruben J., et al.
Publicado: (2012)

Using median survival in meta-analysis of experimental time-to-event data
por: Hirst, Theodore C., et al.
Publicado: (2021)

Psychoanalysis and the Brain – Why Did Freud Abandon Neuroscience?
por: Northoff, Georg
Publicado: (2012)

It’s Awful, Why Did Nobody See it Coming?
por: Noy, Ilan, et al.
Publicado: (2020)

Why Did (Almost) No One See the Inflation Coming?
por: Furman, Jason
Publicado: (2022)

Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke
por: Vesterinen, Hanna M, et al.
Publicado: (2013)

The promise of anti-angiogenic cancer therapy
por: Oehler, M K, et al.
Publicado: (2000)

Improving our understanding of the in vivo modelling of psychotic disorders: A protocol for a systematic review and meta‐analysis
por: Bahor, Zsanett, et al.
Publicado: (2017)

Increased T cell trafficking as adjunct therapy for HIV-1
por: Fryer, Helen R., et al.
Publicado: (2018)

Why Henry III of Navarre’s Hair Probably did not Turn White Overnight
por: Navarini, Alexander A, et al.
Publicado: (2010)

Why, when, and how did yeast evolve alcoholic fermentation?
por: Dashko, Sofia, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dsonv3jnj22i7dsu9ab1hj9r2s