Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation

Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational di...

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Detalles Bibliográficos
Autores principales: Mo, Yuxiang, Lei, Jiangtao, Sun, Yunxiang, Zhang, Qingwen, Wei, Guanghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020610/
https://www.ncbi.nlm.nih.gov/pubmed/27620620
http://dx.doi.org/10.1038/srep33076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020610/
https://www.ncbi.nlm.nih.gov/pubmed/27620620
http://dx.doi.org/10.1038/srep33076

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