A combination of two antibodies recognizing non‐overlapping epitopes of HER2 induces kinase activity‐dependent internalization of HER2

The human epidermal growth factor receptor 2 (HER2/ErbB2) is overexpressed in a number of human cancers. HER2 is the preferred heterodimerization partner for other epidermal growth factor receptor (EGFR) family members and is considered to be resistant to endocytic down‐regulation, properties which...

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Detalles Bibliográficos
Autores principales: Szymanska, Monika, Fosdahl, Anne M., Nikolaysen, Filip, Pedersen, Mikkel W., Grandal, Michael M., Stang, Espen, Bertelsen, Vibeke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020627/
https://www.ncbi.nlm.nih.gov/pubmed/27469139
http://dx.doi.org/10.1111/jcmm.12899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020627/
https://www.ncbi.nlm.nih.gov/pubmed/27469139
http://dx.doi.org/10.1111/jcmm.12899

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