LIGHT/IFN‐γ triggers β cells apoptosis via NF‐κB/Bcl2‐dependent mitochondrial pathway

LIGHT recruits and activates naive T cells in the islets at the onset of diabetes. IFN‐γ secreted by activated T lymphocytes is involved in beta cell apoptosis. However, whether LIGHT sensitizes IFNγ‐induced beta cells destruction remains unclear. In this study, we used the murine beta cell line MIN...

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Detalles Bibliográficos
Autores principales: Zheng, Quan‐You, Cao, Zhao‐Hui, Hu, Xiao‐Bo, Li, Gui‐Qing, Dong, Shi‐Fang, Xu, Gui‐Lian, Zhang, Ke‐Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020636/
https://www.ncbi.nlm.nih.gov/pubmed/27241100
http://dx.doi.org/10.1111/jcmm.12876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020636/
https://www.ncbi.nlm.nih.gov/pubmed/27241100
http://dx.doi.org/10.1111/jcmm.12876

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