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Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

The conversion of peptides or proteins from their soluble native states into intractable amyloid deposits is associated with a wide range of human disorders. Misfolded protein oligomers formed during the process of aggregation have been identified as the primary pathogenic agents in many such condit...

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Detalles Bibliográficos
Autores principales: Evangelisti, Elisa, Cascella, Roberta, Becatti, Matteo, Marrazza, Giovanna, Dobson, Christopher M., Chiti, Fabrizio, Stefani, Massimo, Cecchi, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020652/
https://www.ncbi.nlm.nih.gov/pubmed/27619987
http://dx.doi.org/10.1038/srep32721