4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells

Excessive reactive oxygen species (ROS) induces oxidative damage to cellular constituents, ultimately leading to induction of apoptotic cell death and the pathogenesis of various diseases. The molecular mechanisms for the action of ROS in intestinal diseases remain poorly defined. Here, we reported...

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Detalles Bibliográficos
Autores principales: Ji, Yun, Dai, Zhaolai, Wu, Guoyao, Wu, Zhenlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020658/
https://www.ncbi.nlm.nih.gov/pubmed/27620528
http://dx.doi.org/10.1038/srep32929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020658/
https://www.ncbi.nlm.nih.gov/pubmed/27620528
http://dx.doi.org/10.1038/srep32929

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