Logical design of an anti‐cancer agent targeting the plant homeodomain in Pygopus2

Pygopus2 (Pygo2) is a component of the Wnt signaling pathway, which is required for β‐catenin mediated transcription. Plant homeodomain (PHD) finger in Pygo2 intercalates the methylated histone 3 (H3K4me) tail and HD1 domain of BCL9 that binds to β‐catenin. Thus, PHD finger may be a potential target...

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Detalles Bibliográficos
Autores principales: Ali, Ferdausi, Yamaguchi, Keiichi, Fukuoka, Mayuko, Elhelaly, Abdelazim Elsayed, Kuwata, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021024/
https://www.ncbi.nlm.nih.gov/pubmed/27324116
http://dx.doi.org/10.1111/cas.12995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021024/
https://www.ncbi.nlm.nih.gov/pubmed/27324116
http://dx.doi.org/10.1111/cas.12995

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