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Logical design of an anti‐cancer agent targeting the plant homeodomain in Pygopus2

Pygopus2 (Pygo2) is a component of the Wnt signaling pathway, which is required for β‐catenin mediated transcription. Plant homeodomain (PHD) finger in Pygo2 intercalates the methylated histone 3 (H3K4me) tail and HD1 domain of BCL9 that binds to β‐catenin. Thus, PHD finger may be a potential target...

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Detalles Bibliográficos
Autores principales:	Ali, Ferdausi, Yamaguchi, Keiichi, Fukuoka, Mayuko, Elhelaly, Abdelazim Elsayed, Kuwata, Kazuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021024/ https://www.ncbi.nlm.nih.gov/pubmed/27324116 http://dx.doi.org/10.1111/cas.12995

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