Beyond the SNARE: Munc18-1 chaperones α-synuclein

Early infantile epileptic encephalopathy (EIEE)–associated mutations in MUNC18-1 cause Munc18-1 misfolding and cellular aggregation. In this issue, Chai et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregate...

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Detalles Bibliográficos
Autores principales: Deshpande, Mugdha, Rodal, Avital A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021099/
https://www.ncbi.nlm.nih.gov/pubmed/27597757
http://dx.doi.org/10.1083/jcb.201608060
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author Deshpande, Mugdha
Rodal, Avital A.
author_facet Deshpande, Mugdha
Rodal, Avital A.
author_sort Deshpande, Mugdha
collection PubMed
description Early infantile epileptic encephalopathy (EIEE)–associated mutations in MUNC18-1 cause Munc18-1 misfolding and cellular aggregation. In this issue, Chai et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote α-synuclein aggregation.
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spelling pubmed-50210992017-03-12 Beyond the SNARE: Munc18-1 chaperones α-synuclein Deshpande, Mugdha Rodal, Avital A. J Cell Biol Commentary Early infantile epileptic encephalopathy (EIEE)–associated mutations in MUNC18-1 cause Munc18-1 misfolding and cellular aggregation. In this issue, Chai et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote α-synuclein aggregation. The Rockefeller University Press 2016-09-12 /pmc/articles/PMC5021099/ /pubmed/27597757 http://dx.doi.org/10.1083/jcb.201608060 Text en © 2016 Deshpande and Rodal This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Deshpande, Mugdha
Rodal, Avital A.
Beyond the SNARE: Munc18-1 chaperones α-synuclein
title Beyond the SNARE: Munc18-1 chaperones α-synuclein
title_full Beyond the SNARE: Munc18-1 chaperones α-synuclein
title_fullStr Beyond the SNARE: Munc18-1 chaperones α-synuclein
title_full_unstemmed Beyond the SNARE: Munc18-1 chaperones α-synuclein
title_short Beyond the SNARE: Munc18-1 chaperones α-synuclein
title_sort beyond the snare: munc18-1 chaperones α-synuclein
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021099/
https://www.ncbi.nlm.nih.gov/pubmed/27597757
http://dx.doi.org/10.1083/jcb.201608060
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