Nuc‐ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination

Nuc‐ErbB3 an alternative transcript from the ErbB3 locus binds to a specific DNA motif and associates with Schwann cell chromatin. Here we generated a nuc‐ErbB3 knockin mouse that lacks nuc‐ErbB3 expression in the nucleus without affecting the neuregulin‐ErbB3 receptor signaling. Nuc‐ErbB3 knockin m...

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Detalles Bibliográficos
Autores principales: Ness, Jennifer K., Skiles, Amanda A., Yap, Eng‐Hui, Fajardo, Eduardo J., Fiser, Andras, Tapinos, Nikos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021170/
https://www.ncbi.nlm.nih.gov/pubmed/27017927
http://dx.doi.org/10.1002/glia.22977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021170/
https://www.ncbi.nlm.nih.gov/pubmed/27017927
http://dx.doi.org/10.1002/glia.22977

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