RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

Sialic acid-binding lectin obtained from bullfrog eggs (SBL) induces cell death in cancer cells but not in normal cells. This antitumor effect is mediated through its ribo-nuclease (RNase) activity. However, the underlying molecular mechanisms remain unclear. We found that the p38 mitogen-activated...

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Detalles Bibliográficos
Autores principales: Kariya, Yukiko, Tatsuta, Takeo, Sugawara, Shigeki, Kariya, Yoshinobu, Nitta, Kazuo, Hosono, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021245/
https://www.ncbi.nlm.nih.gov/pubmed/27513956
http://dx.doi.org/10.3892/ijo.2016.3656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021245/
https://www.ncbi.nlm.nih.gov/pubmed/27513956
http://dx.doi.org/10.3892/ijo.2016.3656

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