SPARC Regulates Transforming Growth Factor Beta Induced (TGFBI) Extracellular Matrix Deposition and Paclitaxel Response in Ovarian Cancer Cells

TGFBI has been shown to sensitize ovarian cancer cells to the cytotoxic effects of paclitaxel via an integrin receptor-mediated mechanism that modulates microtubule stability. Herein, we determine that TGFBI localizes within organized fibrillar structures in mesothelial-derived ECM. We determined th...

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Detalles Bibliográficos
Autores principales: Tumbarello, David A., Andrews, Melissa R., Brenton, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021370/
https://www.ncbi.nlm.nih.gov/pubmed/27622658
http://dx.doi.org/10.1371/journal.pone.0162698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021370/
https://www.ncbi.nlm.nih.gov/pubmed/27622658
http://dx.doi.org/10.1371/journal.pone.0162698

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