Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

OBJECTIVE: It has been thought that the depletion of insulin is responsible for the catabolic consequences of diabetes; however, evidence suggests that glucagon also plays a role in diabetes pathogenesis. Glucagon suppression by glucagon receptor (Gcgr) gene deletion, glucagon immunoneutralization,...

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Detalles Bibliográficos
Autores principales: Neumann, Ursula H., Ho, Jessica S.S., Mojibian, Majid, Covey, Scott D., Charron, Maureen J., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021664/
https://www.ncbi.nlm.nih.gov/pubmed/27656411
http://dx.doi.org/10.1016/j.molmet.2016.05.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021664/
https://www.ncbi.nlm.nih.gov/pubmed/27656411
http://dx.doi.org/10.1016/j.molmet.2016.05.014

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