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Cyclophilin D Is Involved in the Regulation of Autophagy and Affects the Lifespan of P. anserina in Response to Mitochondrial Oxidative Stress

The mitochondrial permeability transition pore plays a key role in programmed cell death and the induction of autophagy. Opening of the pore is regulated by the mitochondrial peptidyl prolyl-cis, trans-isomerase cyclophilin D (CYPD). Previously it was shown in the aging model organism Podospora anse...

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Detalles Bibliográficos
Autores principales: Kramer, Piet, Jung, Alexander T., Hamann, Andrea, Osiewacz, Heinz D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021683/
https://www.ncbi.nlm.nih.gov/pubmed/27683587
http://dx.doi.org/10.3389/fgene.2016.00165