The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells

N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown. Recently, DMT has been found to activate the sigma-1 receptor (Sig-1R), an intracellular chaperone fulfilling...

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Detalles Bibliográficos
Autores principales: Szabo, Attila, Kovacs, Attila, Riba, Jordi, Djurovic, Srdjan, Rajnavolgyi, Eva, Frecska, Ede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021697/
https://www.ncbi.nlm.nih.gov/pubmed/27683542
http://dx.doi.org/10.3389/fnins.2016.00423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021697/
https://www.ncbi.nlm.nih.gov/pubmed/27683542
http://dx.doi.org/10.3389/fnins.2016.00423

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