Cargando…

A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs

Thiopurine methyltransferase (TPMT) and inosine triphosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs: azathioprine and 6-mercaptopurine, used in the treatment of leukemia or inflammatory bowel diseases (IBD). The activity in these enzymes correlates with the genet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skrzypczak-Zielinska, Marzena, Borun, Pawel, Bartkowiak-Kaczmarek, Anna, Zakerska-Banaszak, Oliwia, Walczak, Michal, Dobrowolska, Agnieszka, Kurzawski, Mateusz, Waszak, Malgorzata, Lipinski, Daniel, Plawski, Andrzej, Slomski, Ryszard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021755/ https://www.ncbi.nlm.nih.gov/pubmed/27307154 http://dx.doi.org/10.1007/s40291-016-0217-0

Ejemplares similares

Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease
por: Zakerska-Banaszak, Oliwia, et al.
Publicado: (2022)

Pharmacogenetics of Cannabinoids
por: Hryhorowicz, Szymon, et al.
Publicado: (2017)

The effect of UGT1A9, CYP2B6 and CYP2C9 genes polymorphism on individual differences in propofol pharmacokinetics among Polish patients undergoing general anaesthesia
por: Mikstacki, Adam, et al.
Publicado: (2016)

Alterations in Gut Microbiota Composition in Patients with COVID-19: A Pilot Study of Whole Hypervariable 16S rRNA Gene Sequencing
por: Mańkowska-Wierzbicka, Dorota, et al.
Publicado: (2023)

Impact of CYP2E1, GSTA1 and GSTP1 gene variants on serum alpha glutathione S-transferase level in patients undergoing anaesthesia
por: Mikstacki, Adam, et al.
Publicado: (2016)

Dysbiosis of gut microbiota in Polish patients with ulcerative colitis: a pilot study
por: Zakerska-Banaszak, Oliwia, et al.
Publicado: (2021)

Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn’s disease patients
por: Lykowska-Szuber, Liliana, et al.
Publicado: (2023)

The Effectiveness of Multi-Session FMT Treatment in Active Ulcerative Colitis Patients: A Pilot Study
por: Mańkowska-Wierzbicka, Dorota, et al.
Publicado: (2020)

Is Polymorphism in the Apoptosis and Inflammatory Pathway Genes Associated With a Primary Response to Anti-TNF Therapy in Crohn’s Disease Patients?
por: Walczak, Michal, et al.
Publicado: (2020)

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review
por: Krela-Kaźmierczak, Iwona, et al.
Publicado: (2022)

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk
por: Nguyen, Christine M., et al.
Publicado: (2011)

Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia
por: Zakerska-Banaszak, Oliwia, et al.
Publicado: (2017)

Comparative-high resolution melting: a novel method of simultaneous screening for small mutations and copy number variations
por: Borun, Pawel, et al.
Publicado: (2013)

NGS study of glucocorticoid response genes in inflammatory bowel disease patients
por: Skrzypczak-Zielinska, Marzena, et al.
Publicado: (2019)

In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8
por: Wennerstrand, Patricia, et al.
Publicado: (2017)

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia
por: Farfan, Mauricio J, et al.
Publicado: (2014)

Effect of Anti-TNF Therapy on Mucosal Apoptosis Genes Expression in Crohn's Disease
por: Lykowska-Szuber, Liliana, et al.
Publicado: (2021)

MYH Gene Status in Polish FAP Patients without APC Gene Mutations
por: Skrzypczak, Marzena, et al.
Publicado: (2006)

Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis
por: Miao, Qiang, et al.
Publicado: (2021)

The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia
por: Lee, Jae Min, et al.
Publicado: (2021)

Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT
por: Harmand, Pierre-Olivier, et al.
Publicado: (2020)

Familial adenomatous polyposis of the colon
por: Plawski, Andrzej, et al.
Publicado: (2013)

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
por: Zhou, Hong, et al.
Publicado: (2018)

ITPA, TPMT, and NUDT15 Genetic Polymorphisms Predict 6-Mercaptopurine Toxicity in Middle Eastern Children With Acute Lymphoblastic Leukemia
por: Moradveisi, Borhan, et al.
Publicado: (2019)

Influence of lactose intolerance on colorectal cancer incidence in the Polish population
por: Andrzej, Plawski, et al.
Publicado: (2015)

Microchimerism in twins
por: Waszak, Małgorzata, et al.
Publicado: (2013)

The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn’s Disease
por: Ha, Changhee, et al.
Publicado: (2020)

Susceptibility to thiopurine toxicity by TPMT and NUDT15 variants in Colombian children with acute lymphoblastic leukemia
por: Correa-Jimenez, Oscar, et al.
Publicado: (2021)

CCND1 gene polymorphic variants in patients with differentiated thyroid carcinoma
por: HRYHOROWICZ, SZYMON, et al.
Publicado: (2015)

Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia
por: Milosevic, Goran, et al.
Publicado: (2018)

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China
por: Mao, Xiaoyan, et al.
Publicado: (2021)

Myostatin and Follistatin—New Kids on the Block in the Diagnosis of Sarcopenia in IBD and Possible Therapeutic Implications
por: Skrzypczak, Dorota, et al.
Publicado: (2021)

TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned
por: Goh, Liuh Ling, et al.
Publicado: (2022)

Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review
por: Hryhorowicz, Szymon, et al.
Publicado: (2021)

TPMT and DPD Polymorphisms: Efficient Screening Method for Indian Patients Considering Taking Thiopurine and 5-FU Drugs
por: Ashavaid, T. F., et al.
Publicado: (2009)

Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics
por: Neuraz, Antoine, et al.
Publicado: (2013)

Risk factors for thiopurine‐induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype
por: Broekman, M. M. T. J., et al.
Publicado: (2017)

Thiopurines in the Management of Crohn's Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study
por: Benmassaoud, Amine, et al.
Publicado: (2016)

A method of rapid and cost-effective screening for small mutations in patients with Peutz-Jeghers Syndrome
por: Boruń, Paweł, et al.
Publicado: (2012)

Does the VDR gene polymorphism influence the efficacy of denosumab therapy in postmenopausal osteoporosis?
por: Wawrzyniak, Anna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_39j6ji12rd7ui326v9n7r29d9u