A sliding-bulge structure at the Dicer processing site of pre-miRNAs regulates alternative Dicer processing to generate 5′-isomiRs

5′-isomiRs expand the repertoire of miRNA targets. However, how they are generated is not well understood. Previously, we showed that for some miRNAs in mammalian cells, Drosha cleaves at multiple sites to generate multiple pre-miRNAs that give rise to multiple 5′-isomiRs. Here, we showed that for s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Hongming, Wu, Yonggan, Niu, Qi, Zhang, Junli, Jia, Gengxiang, Manjunath, N., Wu, Haoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021778/
https://www.ncbi.nlm.nih.gov/pubmed/27656682
http://dx.doi.org/10.1016/j.heliyon.2016.e00148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021778/
https://www.ncbi.nlm.nih.gov/pubmed/27656682
http://dx.doi.org/10.1016/j.heliyon.2016.e00148

Ejemplares similares