Improved bioavailability of timolol maleate via transdermal transfersomal gel: Statistical optimization, characterization, and pharmacokinetic assessment

Timolol maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short elimination half-life of 4 h; parameters necessit...

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Detalles Bibliográficos
Autores principales: Morsi, Nadia M., Aboelwafa, Ahmed A., Dawoud, Marwa H.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021919/
https://www.ncbi.nlm.nih.gov/pubmed/27660724
http://dx.doi.org/10.1016/j.jare.2016.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021919/
https://www.ncbi.nlm.nih.gov/pubmed/27660724
http://dx.doi.org/10.1016/j.jare.2016.07.003

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