The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1

Liver injury is a common adverse effect of atorvastatin. This study aimed to investigate atorvastatin-induced hepatotoxicity in diabetic rats induced by high-fat diet combined with streptozotocin. The results showed that 40 mg/kg atorvastatin was lethal to diabetic rats, whose mean survival time was...

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Detalles Bibliográficos
Autores principales: Shu, Nan, Hu, Mengyue, Ling, Zhaoli, Liu, Peihua, Wang, Fan, Xu, Ping, Zhong, Zeyu, Sun, Binbin, Zhang, Mian, Li, Feng, Xie, Qiushi, Liu, Xiaodong, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021965/
https://www.ncbi.nlm.nih.gov/pubmed/27624558
http://dx.doi.org/10.1038/srep33072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021965/
https://www.ncbi.nlm.nih.gov/pubmed/27624558
http://dx.doi.org/10.1038/srep33072

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