Cargando…

NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy

Alcoholic cardiomyopathy (ACM) resulting from excess alcohol consumption is an important cause of heart failure (HF). Although it is assumed that the cardiotoxicity of the ethanol (EtOH)-metabolite acetaldehyde (ACA) is central for its development and progression, the exact mechanisms remain obscure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brandt, Moritz, Garlapati, Venkata, Oelze, Matthias, Sotiriou, Efthymios, Knorr, Maike, Kröller-Schön, Swenja, Kossmann, Sabine, Schönfelder, Tanja, Morawietz, Henning, Schulz, Eberhard, Schultheiss, Heinz-Peter, Daiber, Andreas, Münzel, Thomas, Wenzel, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021994/ https://www.ncbi.nlm.nih.gov/pubmed/27624556 http://dx.doi.org/10.1038/srep32554

Ejemplares similares

Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system
por: Daiber, Andreas, et al.
Publicado: (2017)

NOX2ko Mice Show Largely Increased Expression of a Mutated NOX2 mRNA Encoding an Inactive NOX2 Protein
por: Göllner, Monika, et al.
Publicado: (2020)

New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease
por: Daiber, Andreas, et al.
Publicado: (2019)

Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases
por: Daiber, Andreas, et al.
Publicado: (2020)

The AMP-Activated Protein Kinase Plays a Role in Antioxidant Defense and Regulation of Vascular Inflammation
por: Jansen, Thomas, et al.
Publicado: (2020)

Development of an Analytical Assay for Electrochemical Detection and Quantification of Protein-Bound 3-Nitrotyrosine in Biological Samples and Comparison with Classical, Antibody-Based Methods
por: Vujacic-Mirski, Ksenija, et al.
Publicado: (2020)

The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation
por: Steven, Sebastian, et al.
Publicado: (2018)

Comparison of Mitochondrial Superoxide Detection Ex Vivo/In Vivo by mitoSOX HPLC Method with Classical Assays in Three Different Animal Models of Oxidative Stress
por: Kalinovic, Sanela, et al.
Publicado: (2019)

Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension
por: Steven, Sebastian, et al.
Publicado: (2017)

The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk
por: Münzel, Thomas, et al.
Publicado: (2018)

Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis
por: Bayo Jimenez, Maria Teresa, et al.
Publicado: (2021)

Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling
por: Jansen, Thomas, et al.
Publicado: (2021)

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
por: Steven, Sebastian, et al.
Publicado: (2019)

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice
por: Münzel, Thomas, et al.
Publicado: (2017)

Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy
por: Schuhmacher, Swenja, et al.
Publicado: (2011)

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation
por: Kröller-Schön, Swenja, et al.
Publicado: (2018)

The Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin Improves Diabetes-Induced Vascular Dysfunction in the Streptozotocin Diabetes Rat Model by Interfering with Oxidative Stress and Glucotoxicity
por: Oelze, Matthias, et al.
Publicado: (2014)

The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
por: Steven, Sebastian, et al.
Publicado: (2017)

GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation
por: Helmstädter, Johanna, et al.
Publicado: (2021)

Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
por: Oelze, Matthias, et al.
Publicado: (2010)

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension
por: Helmstädter, Johanna, et al.
Publicado: (2020)

T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of (·)NO/cGMP Signaling
por: Schüler, Rebecca, et al.
Publicado: (2019)

Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2)
por: Kuntic, Marin, et al.
Publicado: (2020)

Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD(+/- )mice
por: Mollnau, Hanke, et al.
Publicado: (2006)

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects
por: Frenis, Katie, et al.
Publicado: (2021)

Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice
por: Brandt, Moritz, et al.
Publicado: (2018)

Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats
por: Stamm, P, et al.
Publicado: (2015)

Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension
por: Steven, Sebastian, et al.
Publicado: (2020)

Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide
por: Stein, Judith, et al.
Publicado: (2017)

Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all‐comer population of patients with heart failure: a retrospective analysis
por: Sotiriou, Efthymios, et al.
Publicado: (2018)

Interplay of NK cells and monocytes in vascular inflammation and myocardial infarction
por: Knorr, Maike, et al.
Publicado: (2014)

Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice
por: Lagrange, Jeremy, et al.
Publicado: (2020)

Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice
por: Kiouptsi, Klytaimnistra, et al.
Publicado: (2018)

Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis
por: Schönfelder, Tanja, et al.
Publicado: (2018)

E-cigarette effects on vascular function in animals and humans
por: Daiber, Andreas, et al.
Publicado: (2023)

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
por: Karbach, Susanne H., et al.
Publicado: (2016)

Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1–driven fibrotic remodeling in ischemic heart failure
por: Garlapati, Venkata, et al.
Publicado: (2023)

Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction
por: Molitor, Michael, et al.
Publicado: (2023)

Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
por: Frenis, Katie, et al.
Publicado: (2022)

PGC-1α dictates endothelial function through regulation of eNOS expression
por: Craige, Siobhan M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9e21id0punliavh85b89tbdrl4